基因名：
MDM4
产品别名：
BMFS6； HDMX； MDMX； MRP1； MDM4； MDM4 regulator of p53； MDM4 regulator of p53； protein Mdm4； MDM4, p53 regulator； MDM4-related protein 1； Mdm4 p53 binding protein homolog； double minute 4, human homolog of; p53-binding protein； mdm2-like p53-binding protein； protein Mdmx； MDM2样P53蛋白结合； 磷酸化MDM2样P53结合蛋白；
背景信息：
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.Region I is sufficient for binding TP53 and inhibiting its G1 arrest and apoptosis functions. It also binds TP73. Region II contains most of a central acidic region and a putative C4-type zinc finger. The RING finger domain which coordinates two molecules of zinc mediates the heterooligomerization with MDM2.
