基因名：
MCM3
产品别名：
HCC5； P1-MCM3； P1.h； RLFB； MCM3； minichromosome maintenance complex component 3； minichromosome maintenance complex component 3； DNA replication licensing factor MCM3； DNA polymerase alpha holoenzyme-associated protein P1； DNA replication factor MCM3； MCM3 minichromosome maintenance deficient 3； RLF subunit beta； cervical cancer proto-oncogene 5； hRlf beta subunit； minichromosome maintenance deficient 3； p102； replication licensing factor, beta subunit； 微小染色体维持缺陷蛋白3； 微小染色体维持缺陷蛋白3(MCM3)；
背景信息：
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
