基因名：
MCL1
产品别名：
BCL2L3； EAT； MCL1-ES； MCL1L； MCL1S； Mcl-1； TM； bcl2-L-3； mcl1/EAT； MCL1； MCL1 apoptosis regulator, BCL2 family member； MCL1 apoptosis regulator, BCL2 family member； induced myeloid leukemia cell differentiation protein Mcl-1； BCL2 family apoptosis regulator； MCL1, BCL2 family apoptosis regulator； bcl-2-like protein 3； bcl-2-related protein EAT/mcl1； myeloid cell leukemia 1； myeloid cell leukemia ES； myeloid cell leukemia sequence 1 (BCL2-related)； Bcl2相关髓细胞白血病序列1(MCL1)； 磷酸化髓样细胞白血病-1； 磷酸化髓样细胞白血病1； 髓样细胞白血病-1；
背景信息：
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.
