基因名：
MATK
产品别名：
CHK； CTK； HHYLTK； HYL； HYLTK； Lsk； MATK； megakaryocyte-associated tyrosine kinase； megakaryocyte-associated tyrosine kinase； megakaryocyte-associated tyrosine-protein kinase； CSK homologous kinase； Csk-homologous kinase； Csk-type protein tyrosine kinase； HYL tyrosine kinase； hematopoietic consensus tyrosine-lacking kinase； hydroxyaryl-protein kinase； leukocyte carboxyl-terminal src kinase related； protein kinase HYL； tyrosine kinase MATK； tyrosine-protein kinase CTK； tyrosylprotein kinase； 巨核细胞关联酪氨酸激酶(MATK)； 酪氨酸蛋白激酶细胞分裂素；
背景信息：
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. MATK is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
