基因名：
MAPT
产品别名：
DDPAC； FTDP-17； MAPTL； MSTD； MTBT1； MTBT2； PPND； PPP1R103； TAU； tau-40； MAPT； microtubule associated protein tau； microtubule associated protein tau； microtubule-associated protein tau； G protein beta1/gamma2 subunit-interacting factor 1； PHF-tau； neurofibrillary tangle protein； paired helical filament-tau； protein phosphatase 1, regulatory subunit 103； 微管关联蛋白τ(MAPT)； 微管相关蛋白； 微管相关蛋白Tau-4； 微管相关蛋白亚型4蛋白； 成对螺旋细丝蛋白； 磷酸化微管相关蛋白；
背景信息：
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer"s disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau"s main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs.Tau-F is known as "2N4R," "Isoform Tau-F," "Tau-4" or "Tau 441", which consisting of 441 amino acid. Tau-F is a potential therapeutic target for pathogenesis.
