基因名:
MAP1B
产品别名:
DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9; MAP1B; microtubule associated protein 1B; microtubule associated protein 1B; microtubule-associated protein 1B; protein phosphatase 1, regulatory subunit 102; 微管关联蛋白1B(MAP1B); 微管相关蛋白1B;
背景信息:
Microtubules, the primary component of the cytoskeletal network, interact with proteins called microtubule-associated proteins (MAPs). The microtubule-associated proteins can be divided into two groups, structural and dynamic. The structural microtubule-associated proteins, MAP-1A, MAP-1B, MAP-2A, MAP-2B and MAP-2C, stimulate tubulin assembly, enhance microtubule stability and influence the spatial distribution of microtubules within cells. Both MAP-1 and, to a greater extent, MAP-2 have been implicated as agents of microtubule depolymerization by suppressing the dynamic instability of the microtubules. The suppression of microtubule dynamic instability by the MAP proteins is thought to be associated with phosphorylation of the MAPs.