基因名:
LIMK1
产品别名:
LIMK; LIMK-1; LIMK1; LIM domain kinase 1; LIM domain kinase 1; LIM domain kinase 1; LIM motif-containing protein kinase; 单丝氨酸蛋白激酶1; 单丝氨酸蛋白激酶1+2; 磷酸化单丝氨酸蛋白激酶1; 磷酸化单丝氨酸蛋白激酶1/2;
背景信息:
LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.