基因名：
LCK
产品别名：
IMD22； LSK； YT16； p56lck； pp58lck； LCK； LCK proto-oncogene, Src family tyrosine kinase； LCK proto-oncogene, Src family tyrosine kinase； tyrosine-protein kinase Lck； T-lymphocyte specific protein tyrosine kinase p56lck； leukocyte C-terminal Src kinase； lymphocyte cell-specific protein-tyrosine kinase； p56(LSTRA) protein-tyrosine kinase； proto-oncogene tyrosine-protein kinase LCK； t cell-specific protein-tyrosine kinase； 淋巴细胞特异性蛋白酪氨酸激酶； 磷酸化淋巴细胞特异性蛋白酪氨酸激酶； 酪氨酸蛋白激酶Lck蛋白；
背景信息：
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
