基因名：
LAMP2
产品别名：
CD107b； DND； LAMP-2； LAMPB； LGP-96； LGP110； LAMP2； lysosomal associated membrane protein 2； lysosomal associated membrane protein 2； lysosome-associated membrane glycoprotein 2； CD107 antigen-like family member B； 溶酶体关联膜蛋白2(LAMP2)； 溶酶体相关膜蛋白2（CD107B）；
背景信息：
Lysosomal Associated Membrane Protein 2 (LAMP2) is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110kDa. Mature human LAMP2 consists of a 347 amino acid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmic tail . The lumenal domain is organized into two heavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment.LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73,LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.
