基因名：
KRAS
产品别名：
'C-K-RAS； C-K-RAS； CFC2； K-RAS2A； K-RAS2B； K-RAS4A； K-RAS4B； K-Ras； K-Ras 2； KI-RAS； KRAS1； KRAS2； NS； NS3； OES； RALD； RASK2； c-Ki-ras； c-Ki-ras2； KRAS； KRAS proto-oncogene, GTPase； KRAS proto-oncogene, GTPase； GTPase KRas； K-ras p21 protein； Kirsten rat sarcoma viral oncogene homolog； Kirsten rat sarcoma viral proto-oncogene； PR310 c-K-ras oncogene； c-Kirsten-ras protein； cellular c-Ki-ras2 proto-oncogene； cellular transforming proto-oncogene； oncogene KRAS2； proto-oncogene GTPase； transforming protein p21； v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog； V-Ki-Ras2 Kirsten大鼠肉瘤病毒癌基因同源物(KRAS)； 原癌基因K-ras；
背景信息：
K-Ras belongs to the small GTPase superfamily, Ras family. As other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes because of the presence of an isoprenyl group on its C-terminus. K-Ras functions as a molecular on/off switch. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. Besides essential function in normal tissue signaling, the mutation of a K-Ras gene is an essential step in the development of many cancers. Several germline K-Ras mutations have been found to be associated with Noonan syndrome[4] and cardio-facio-cutaneous syndrome. Somatic K-Ras mutations are found at high rates in Leukemias, colon cancer, pancreatic cancer and lung cancer.
