重组NK细胞抑制性受体2DL3蛋白

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重组NK细胞抑制性受体2DL3蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

重组杀伤细胞免疫球蛋白样受体2DL3(KIR2DL3)
Recombinant KIR2DL3

基因名：

KIR2DL3

产品别名：

CD158B2； CD158b； GL183； KIR-023GB； KIR-K7b； KIR-K7c； KIR2DL； KIR2DS5； KIRCL23； NKAT； NKAT2； NKAT2A； NKAT2B； p58； KIR2DL3； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3； killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3； killer cell immunoglobulin-like receptor 2DL3； CD158 antigen-like family member B2； NKAT-2； killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3； killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5； killer inhibitory receptor cl 2-3； natural killer associated transcript 2； natural killer cell inhibitory receptor KIR2DL3； p58 NK receptor CL-6； p58 natural killer cell receptor clone CL-6； p58.2 MHC class-I specific NK receptor； NK细胞抑制性受体2DL3；杀伤细胞免疫球蛋白样受体2DL3(KIR2DL3)；

背景信息：

Killer-Cell Immunoglobulin-Like Receptors (KIRs) are important cells of the immune system. KIRs are a family of Natural Killer (NK) Cells surface glycoproteins. KIRs control the killing function of these cells by interacting with MHC class I molecules. This interaction allows KIRs to identify virally infected cells or tumor cells by the distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor. KIR2DL3 recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.