基因名：
KDR
产品别名：
CD309； FLK1； VEGFR； VEGFR2； KDR； kinase insert domain receptor； kinase insert domain receptor； vascular endothelial growth factor receptor 2； fetal liver kinase-1； kinase insert domain receptor (a type III receptor tyrosine kinase)； protein-tyrosine kinase receptor Flk-1； soluble VEGFR2； tyrosine kinase growth factor receptor； VEGFR2蛋白； 可溶性血管内皮生长因子受体2； 磷酸化血管内皮生长因子受体2； 血管内皮生长因子受体2； 血管内皮生长因子受体2(VEGFR2)； 血管内皮生长因子受体2(VEGFR2)真核蛋白； 血管内皮生长因子受体2蛋白；
背景信息：
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo.The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
