基因名：
KCNA5
产品别名：
ATFB7； HCK1； HK2； HPCN1； KV1.5； PCN1； KCNA5； potassium voltage-gated channel subfamily A member 5； potassium voltage-gated channel subfamily A member 5； potassium voltage-gated channel subfamily A member 5； cardiac potassium channel； insulinoma and islet potassium channel； potassium channel 1； potassium channel, voltage gated shaker related subfamily A, member 5； potassium voltage-gated channel, shaker-related subfamily, member 5； voltage-gated potassium channel HK2； voltage-gated potassium channel protein Kv1.5； voltage-gated potassium channel subunit Kv1.5； 钾电压阀门通道混合器相关亚家族成员5；
背景信息：
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12.
