基因名：
KCNA4
产品别名：
HBK4； HK1； HPCN2； HUKII； KCNA4L； KCNA8； KV1.4； MCIDDS； PCN2； KCNA4； potassium voltage-gated channel subfamily A member 4； potassium voltage-gated channel subfamily A member 4； potassium voltage-gated channel subfamily A member 4； cardiac potassium channel； fetal skeletal muscle potassium channel； potassium channel 2； potassium channel, voltage gated shaker related subfamily A, member 4； rapidly inactivating potassium channel； shaker-related potassium channel Kv1.4； type A potassium channel； voltage-gated K(+) channel HuKII； voltage-gated potassium channel HBK4； voltage-gated potassium channel HK1； voltage-gated potassium channel subunit Kv1.4； 电压门控性钾通道蛋白Kv1.4；
背景信息：
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha-subunits (KV alpha), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KV beta subunits that modify the gating properties of the coexpressed KV alpha subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.
