基因名：
ILF3
产品别名：
CBTF； DRBF； DRBP76； MMP4； MPHOSPH4； MPP4； MPP4110； NF-AT-90； NF110； NF110b； NF90； NF90a； NF90b； NF90c； NF90ctv； NFAR； NFAR-1； NFAR-2； NFAR110； NFAR2； NFAR90； TCP110； TCP80； ILF3； interleukin enhancer binding factor 3； interleukin enhancer binding factor 3； interleukin enhancer-binding factor 3； M phase phosphoprotein 4, nuclear factor associated with DS RNA； M-phase phosphoprotein 4； double-stranded RNA-binding protein, 76 kD； dsRNA binding protein NFAR-2/MPP4； interleukin enhancer binding factor 3, 90kD； interleukin enhancer binding factor 3, 90kDa； nuclear factor associated with dsRNA； nuclear factor of activated T-cells 110 kDa； nuclear factor of activated T-cells 90 kDa； nuclear factor of activated T-cells, 90 kD； translational control protein 80； 白介素增强子结合因子3(ILF3)； 白细胞介素增强子结合因子3；
背景信息：
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
