基因名：
IL12RB1
产品别名：
CD212； IL-12R-BETA1； IL12RB； IMD30； IL12RB1； interleukin 12 receptor subunit beta 1； interleukin 12 receptor subunit beta 1； interleukin-12 receptor subunit beta-1； IL-12 receptor beta component； IL-12 receptor subunit beta-1； IL-12R subunit beta-1； cluster of differentiation 212； interleukin 12 receptor, beta 1； interleukin-12 receptor beta-1 chain； 白介素12受体β1(IL12Rb1)； 白细胞介素-12受体β1；
背景信息：
Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells, NK cells and B cells.
