基因名：
IKBKB
产品别名：
IKK-beta； IKK2； IKKB； IMD15； IMD15A； IMD15B； NFKBIKB； IKBKB； inhibitor of nuclear factor kappa B kinase subunit beta； inhibitor of nuclear factor kappa B kinase subunit beta； inhibitor of nuclear factor kappa-B kinase subunit beta； I-kappa-B kinase 2； I-kappa-B-kinase beta； inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta； nuclear factor NF-kappa-B inhibitor kinase beta； serine/threonine protein kinase IKBKB； B-细胞κ-轻肽基因增强子抑制因子激酶β(IkBKb)； KB抑制蛋白激酶β； 磷酸化KB抑制蛋白激酶β；
背景信息：
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
