基因名：
IGHE
产品别名：
IgE； IGHE； immunoglobulin heavy constant epsilon； immunoglobulin heavy constant epsilon； constant region of heavy chain of IgE； immunoglobulin epsilon； 免疫球蛋白E(IgE)； 免疫球蛋白E(IgE)天然蛋白；
背景信息：
Immunoglobulin E (IgE) is well known for its role in allergic disease, the manifestations of which are mediated through its two Fc receptors, FcεRI and CD23 (FcεRII). IgE and its interactions with these receptors are therefore potential targets for therapeutic intervention, and exciting progress has been made in this direction. Furthermore, recent structural studies of IgE-Fc, the two receptors, and of their complexes, have revealed a remarkable degree of plasticity at the IgE-CD23 interface and an even more remarkable degree of dynamic flexibility within the IgE molecule.
