基因名：
HSD11B2
产品别名：
AME； AME1； HSD11K； HSD2； SDR9C3； HSD11B2； hydroxysteroid 11-beta dehydrogenase 2； hydroxysteroid 11-beta dehydrogenase 2； 11-beta-hydroxysteroid dehydrogenase type 2； -HSD11 type II； 11-DH2； 11-HSD type II； 11-beta-HSD type II； 11-beta-HSD2； 11-beta-hydroxysteroid dehydrogenase type II； NAD-dependent 11-beta-hydroxysteroid dehydrogenase； corticosteroid 11-beta-dehydrogenase isozyme 2； short chain dehydrogenase/reductase family 9C member 3； 11-β-羟基类固醇脱氢酶2(HSD11b2)； 羟基类固醇脱氢酶11β2；
背景信息：
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
