基因名：
PRMT1
产品别名：
ANM1； HCP1； HRMT1L2； IR1B4； PRMT1； protein arginine methyltransferase 1； protein arginine methyltransferase 1； protein arginine N-methyltransferase 1； HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2； heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2； histone-arginine N-methyltransferase PRMT1； interferon receptor 1-bound protein 4； 蛋白精氨酸甲基转移酶1(PRMT1)； 蛋白质精氨酸甲基转移酶1；
背景信息：
PRMTs are a family of proteins that either monomethylate or dimethylate the guanidino nitrogen atoms of arginine side chains. PRMT1 methylates Histone H4 on R3 and acts synergistically with p300/CBP to enhance transcriptional activation by nuclear receptors. PRMT1 also methylates a number of non-histone proteins such as the orphan nuclear receptor HNF4, components of the heterogeneous nuclear ribonucleoprotein (hnRNP) particle, interleukin enhancer-binding factor 3 (ILF3), and interferon alpha and beta receptors. This suggests roles for PRMT1 in transcriptional regulation, mRNA processing and signal transduction. PRMT1 is also a coactivator for p53, methylating histone H4 to facilitate p53-mediated transcription.
