基因名:
HOXB5
产品别名:
HHO.C10; HOX2; HOX2A; HU-1; Hox2.1; HOXB5; homeobox B5; homeobox B5; homeobox protein Hox-B5; homeo box 2A; homeo box B5; homeobox protein HHO.C10; homeobox protein Hox-2A; homeobox protein Hu-1; 同源盒蛋白HOXB5;
背景信息:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008].