基因名：
HLA-DPB1
产品别名：
DPB1； HLA-DP； HLA-DP1B； HLA-DPB； HLA-DPB1； major histocompatibility complex, class II, DP beta 1； major histocompatibility complex, class II, DP beta 1； HLA class II histocompatibility antigen, DP beta 1 chain； HLA class II histocompatibility antigen, DP(W4) beta chain； HLA-DP histocompatibility type, beta-1 subunit； MHC HLA DPB1； MHC class II HLA-DP-beta-1； MHC class II antigen DPB1； 组织相容性复合体2；
背景信息：
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
