基因名：
SERPIND1
产品别名：
D22S673； HC2； HCF2； HCII； HLS2； LS2； THPH10； SERPIND1； serpin family D member 1； serpin family D member 1； heparin cofactor 2； leuserpin 2； protease inhibitor leuserpin-2； serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1； serpin D1； serpin peptidase inhibitor, clade D (heparin cofactor), member 1； 肝素辅因子Ⅱ(HCII)；
背景信息：
SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
