基因名：
GPER1
产品别名：
CEPR； CMKRL2； DRY12； FEG-1； GPCR-Br； GPER； GPR30； LERGU； LERGU2； LyGPR； mER； GPER1； G protein-coupled estrogen receptor 1； G protein-coupled estrogen receptor 1； G-protein coupled estrogen receptor 1； G protein-coupled receptor 30； IL8-related receptor DRY12； chemoattractant receptor-like 2； chemokine receptor-like 2； constitutively expressed peptide-like receptor； flow-induced endothelial G-protein coupled receptor 1； heptahelix receptor； lymphocyte-derived G-protein coupled receptor； membrane estrogen receptor； G蛋白偶联受体30； G蛋白偶联雌激素受体1(GPER)；
背景信息：
G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives.
