基因名：
GFPT1
产品别名：
CMS12； CMSTA1； GFA； GFAT； GFAT 1； GFAT1； GFAT1m； GFPT； GFPT1L； MSLG； GFPT1； glutamine--fructose-6-phosphate transaminase 1； glutamine--fructose-6-phosphate transaminase 1； glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1； D-fructose-6-phosphate amidotransferase 1； glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1； glutamine:fructose-6-phosphate amidotransferase 1； hexosephosphate aminotransferase 1； 谷氨酰胺6-磷酸果糖转移酶； 谷氨酰胺果糖-6-磷酸转氨酶1(GFPT1)；
背景信息：
Glutamine:fructose-6-phosphate amidotransferase (GFAT1) is the first and rate-limiting enzyme for the entry of glucose into the hexosamine biosynthesis pathway (HBP) in mammals. GFAT1, a member of the N-terminal nucleophile class of amidotransferases, converts fructose-6-phosphate into N-acetylglucosamine-6-phosphate. Hyperglycemia-induced insulin resistance, a condition in which exposure to high concentrations of glucose and insulin results in insulin resistance, may result from increased glucose metabolism through the HBP. Hypergylcemia-induced insulin resistance is a characteristic feature of type 2 diabetes. Consequently, GFAT1 is a potential therapeutic target in the treatment of type 2 diabetes.
