基因名：
FOXD1
产品别名：
FKHL8； FREAC-4； FREAC4； FOXD1； forkhead box D1； forkhead box D1； forkhead box protein D1； Forkhead, drosophila, homolog-like 8； forkhead-like 8； forkhead-related activator 4； forkhead-related protein FKHL8； forkhead-related transcription factor 4； 叉头蛋白D1；
背景信息：
FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
