基因名：
FGF4
产品别名：
FGF-4； HBGF-4； HST； HST-1； HSTF-1； HSTF1； K-FGF； KFGF； FGF4； fibroblast growth factor 4； fibroblast growth factor 4； fibroblast growth factor 4； heparin secretory transforming protein 1； heparin-binding growth factor 4； human stomach cancer, transforming factor from FGF-related oncogene； kaposi sarcoma oncogene； oncogene HST； transforming protein KS3； 成纤维细胞生长因子4(FGF4)； 纤维母细胞生长因子4；
背景信息：
Fibroblast growth factor 4(FGF-4) is a heparin binding member of the FGF family. The human FGF4 cDNA encodes 206 amino acids (aa) with a 33 aa signal sequence and a 173 aa mature protein with an FGF homology domain that contains a heparin binding region near the C-terminus. Mature human FGF4 shares 91%, 82%, 94% and 91% aa identity with mouse, rat, canine and bovine FGF4, respectively. Human FGF-4 has been shown to exhibit cross species activity. Expression of FGF-4 and its receptors, FGF R1c, 2c, 3c and 4, is spatially and temporally regulated during embryonic development. FGF-4 is proposed to play a physiologically relevant role in human embryonic stem cell selfrenewal. It promotes stem cell proliferation, but may also aid differentiation depending on context and concentration, and is often included in embryonic stem cell media in vitro. FGF-4 is mitogenic for fibroblasts and endothelial cells in vitro and has autocrine transforming potential. It is a potent angiogenesis promoter in vivo and has been investigated as therapy for coronary artery disease.
