基因名：
FES
产品别名：
FPS； FES； FES proto-oncogene, tyrosine kinase； FES proto-oncogene, tyrosine kinase； tyrosine-protein kinase Fes/Fps； Oncogene FES, feline sarcoma virus； feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog； feline sarcoma oncogene； feline sarcoma/Fujinami avian sarcoma oncogene homolog； p93c-fes； proto-oncogene c-Fes； proto-oncogene c-Fps； proto-oncogene tyrosine-protein kinase Fes/Fps； 原癌基因酪氨酸蛋白激酶FES； 猫科肉瘤癌基因(FES)；
背景信息：
FES is a protooncogene that encodes a protein-tyrosine kinase distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. FES was originally identified as the cellular homolog of several transforming retroviral oncoproteins. FES plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell-cell interaction. Genetic analysis using transgenic mouse model implicate FES in the regulation of inflammation and innate immunity. FES modulates the innate immune response of macrophages to LPS challenge, in part, by regulating the internalization and down-regulation of the TLR4 receptor complex.
