基因名：
FCER1A
产品别名：
FCE1A； FCERIA； FcERI； FCER1A； Fc epsilon receptor Ia； Fc epsilon receptor Ia； high affinity immunoglobulin epsilon receptor subunit alpha； Fc IgE receptor, alpha polypeptide； Fc epsilon RI alpha-chain； Fc fragment of IgE receptor Ia； Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide； Fc-epsilon RI-alpha； FcepsilonRI alpha chain； FcepsilonRIalpha； high affinity immunoglobulin epsilon receptor alpha-subunit； igE Fc receptor subunit alpha； immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide； IgE-Fc受体Ⅰ(FceRI)；
背景信息：
FCER1A is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.
