基因名：
FAP
产品别名：
DPPIV； FAPA； FAPalpha； SIMP； FAP； fibroblast activation protein alpha； fibroblast activation protein alpha； prolyl endopeptidase FAP； 170 kDa melanoma membrane-bound gelatinase； dipeptidyl peptidase FAP； gelatine degradation protease FAP； integral membrane serine protease； post-proline cleaving enzyme； seprase； surface-expressed protease； 成纤维细胞激活蛋白α； 成纤维细胞激活蛋白α(FAPa)； 成纤维细胞激活蛋白α蛋白；
背景信息：
Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein. Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro. Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB).
