基因名：
EXTL3
产品别名：
BOTV； EXTL1L； EXTR1； ISDNA； REGR； RPR； EXTL3； exostosin like glycosyltransferase 3； exostosin like glycosyltransferase 3； exostosin-like 3； EXT-related 1； epididymis secretory sperm binding protein； exostoses (multiple)-like 3； exostosin tumor-like 3； glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase； hereditary multiple exostoses gene isolog； putative tumor suppressor protein EXTL3； reg receptor； 多发性外生骨疣样蛋白3；
背景信息：
EXTL3 is a member of the EXT (hereditary multiple exostosin) gene family of tumor suppressors encoding glycosyltransferases involved in heparan sulfate (HS) biosynthesis. Within this family, the C-terminus is conserved between all members from C. elegans to vertebrates. EXTL3 is a ubiquitously expressed, developmentally regulated, single-pass type II membrane protein that localizes to the endoplasmic reticulum membrane. EXTL3 adds N-acetylglucosamine (GlcNAc) to the polysaccharide-protein linkage region and to the growing HS chain suggesting that it plays a role in both the initiation and elongation of HS chains. In addition, EXTL3 may act as a Reg receptor, binding Reg via its N-terminus.
