基因名：
ESRRB
产品别名：
DFNB35； ERR beta-2； ERR2； ERRb； ERRbeta2； ESRL2； NR3B2； ESRRB； estrogen related receptor beta； estrogen related receptor beta； steroid hormone receptor ERR2； estrogen receptor-like 2； estrogen-related nuclear receptor beta； nuclear receptor ERRB2； nuclear receptor subfamily 3 group B member 2； orphan nuclear receptor； 雌激素受体相关受体β(ERRb)； 雌激素相关受体β；
背景信息：
Estrogen related receptor beta, a NR3 Steroid Receptor, has been shown to affect early placental development. Also it can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). It binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). Estrogen related receptor beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. Expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries. The ligand for the receptor is PPARgamma coactivator 1 (PGC-1) beta.
