基因名：
ESR2
产品别名：
ER-BETA； ESR-BETA； ESRB； ESTRB； Erb； NR3A2； ODG8； ESR2； estrogen receptor 2； estrogen receptor 2； estrogen receptor beta； estrogen receptor beta 2； estrogen receptor beta 4； nuclear receptor subfamily 3 group A member 2； oestrogen receptor beta； 磷酸化雌激素受体β； 雌激素受体β； 雌激素受体β(ERb)； 雌激素受体β蛋白；
背景信息：
Estrogen Receptor Beta (ESR2) is a nuclear protein that belongs to the nuclear hormone receptor family of NR3 subfamily. It contains one nuclear receptor DNA-binding domain and is expressed in many tissues at a lower level. ESR2 is a nuclear hormone receptor. It binds estrogens with an affinity similar to that of ESR1 and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
