基因名：
EP300
产品别名：
KAT3B； MKHK2； RSTS2； p300； EP300； E1A binding protein p300； E1A binding protein p300； histone acetyltransferase p300； E1A-associated protein p300； E1A-binding protein, 300kD； histone butyryltransferase p300； histone crotonyltransferase p300； p300 HAT； protein 2-hydroxyisobutyryltransferase p300； protein lactyltransferas p300； protein propionyltransferase p300； CREB结合蛋白p300； E1A结合蛋白P300(EP300)； 磷酸化转录接头蛋白EP300； 转录接头蛋白EP300；
背景信息：
Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
