基因名：
CELSR2
产品别名：
ADGRC2； CDHF10； EGFL2； Flamingo1； MEGF3； CELSR2； cadherin EGF LAG seven-pass G-type receptor 2； cadherin EGF LAG seven-pass G-type receptor 2； cadherin EGF LAG seven-pass G-type receptor 2； EGF-like protein 2； EGF-like-domain, multiple 2； adhesion G protein-coupled receptor C2； cadherin family member 10； cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)； epidermal growth factor-like 2； epidermal growth factor-like protein 2； flamingo homolog 3； multiple EGF-like domains protein 3； multiple epidermal growth factor-like domains 3； multiple epidermal growth factor-like domains protein 3； 表皮生长因子样蛋白2； 钙粘蛋白EGF LAG七经G-型受体2(CELSR2)；
背景信息：
Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons.
