基因名：
S1PR1
产品别名：
CD363； CHEDG1； D1S3362； ECGF1； EDG-1； EDG1； S1P1； S1PR1； sphingosine-1-phosphate receptor 1； sphingosine-1-phosphate receptor 1； sphingosine 1-phosphate receptor 1； S1P receptor 1； S1P receptor Edg-1； endothelial differentiation G-protein coupled receptor 1； endothelial differentiation, sphingolipid G-protein-coupled receptor, 1； sphingosine 1-phosphate receptor EDG1； sphingosine 1-phosphate receptor Edg-1； 内皮细胞分化鞘脂G蛋白偶联受体1； 磷酸化EDG1； 鞘氨醇1磷酸酯受体1(S1PR1)；
背景信息：
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.
