基因名：
DDIT3
产品别名：
AltDDIT3； C/EBPzeta； CEBPZ； CHOP； CHOP-10； CHOP10； GADD153； DDIT3； DNA damage inducible transcript 3； DNA damage inducible transcript 3； DNA damage-inducible transcript 3 protein； C/EBP zeta； CCAAT/enhancer-binding protein homologous protein； alternative DDIT3 protein； c/EBP-homologous protein 10； growth arrest and DNA damage-inducible protein GADD153； DNA损伤诱导转录因子3(DDIT3)； 磷酸化GADD153；
背景信息：
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010].
