基因名：
DAPK3
产品别名：
DLK； ZIP； ZIPK； DAPK3； death associated protein kinase 3； death associated protein kinase 3； death-associated protein kinase 3； DAP kinase 3； DAP-like kinase； MYPT1 kinase； ZIP-kinase； zipper-interacting protein kinase； 凋亡相关蛋白激酶3； 死亡关联蛋白激酶3(DAPK3)； 磷酸化死亡相关蛋白激酶3；
背景信息：
Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certainserine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel serine/threonine kinase that mediates apoptosis was recently identified and designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a C terminal leucine zipper structure and binds to ATF4 that is a member of ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death associated protein kinase), which is a mediator of apoptosis induced by gamma interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP kinases represent a novel kinase family, which mediates apoptosis through their catalytic activities. The messenger RNA was ubiquitously expressed in various tissues.
