基因名：
DAB2
产品别名：
DOC-2； DOC2； DAB2； DAB adaptor protein 2； DAB adaptor protein 2； disabled homolog 2； DAB2, clathrin adaptor protein； Dab, mitogen-responsive phosphoprotein, homolog 2； adaptor molecule disabled-2； differentially expressed in ovarian carcinoma 2； differentially-expressed protein 2； disabled homolog 2, mitogen-responsive phosphoprotein； Disabled同源物2(DAB2)； 信号转导功能磷蛋白DAB2； 磷酸化信号转导功能磷蛋白DAB2；
背景信息：
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
