基因名：
MAP3K8
产品别名：
AURA2； COT； EST； ESTF； MEKK8； TPL2； Tpl-2； c-COT； MAP3K8； mitogen-activated protein kinase kinase kinase 8； mitogen-activated protein kinase kinase kinase 8； mitogen-activated protein kinase kinase kinase 8； Ewing sarcoma transformant； augmented in rheumatoid arthritis 2； cot (cancer Osaka thyroid) oncogene； proto-oncogene c-Cot； proto-oncogene serine/threoine protein kinase； tumor progression locus 2； 丝裂原活化蛋白激酶激酶8； 磷酸化丝裂原活化蛋白激酶激酶8；
背景信息：
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
