基因名：
CEACAM8
产品别名：
CD66b； CD67； CGM6； NCA-95； CEACAM8； CEA cell adhesion molecule 8； CEA cell adhesion molecule 8； carcinoembryonic antigen-related cell adhesion molecule 8； CD67 antigen； carcinoembryonic antigen CGM6； carcinoembryonic antigen gene family member 6； carcinoembryonic antigen related cell adhesion molecule 8； non-specific cross-reacting antigen NCA-95； 癌胚抗原相关细胞粘附分子8； 癌胚抗原相关细胞粘附分子8(CEACAM8)；
背景信息：
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 (CEACAM8) is a single chain, GPI-anchored, highly glycosylated protein which belongs to the immunoglobulin superfamily and the carcinoembryonic antigen(CEA) family. CEACAM8 is expressed by neutrophils and eosinophils, and serves as a binding partner for CEACAM-6 and Galectin-3. It contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. Mature human CEACAM8 is a 287 amino acid GPI-linked glycoprotein. CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells.
