基因名：
CDKN1C
产品别名：
BWCR； BWS； KIP2； WBS； p57； p57Kip2； CDKN1C； cyclin dependent kinase inhibitor 1C； cyclin dependent kinase inhibitor 1C； cyclin-dependent kinase inhibitor 1C； cyclin-dependent kinase inhibitor 1C (p57, Kip2)； cyclin-dependent kinase inhibitor p57； 周期蛋白依赖激酶抑制因子1C； 磷酸化周期蛋白依赖激酶抑制因子1C；
背景信息：
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
