基因名：
CDK8
产品别名：
IDDHBA； K35； CDK8； cyclin dependent kinase 8； cyclin dependent kinase 8； cyclin-dependent kinase 8； CDK8 protein kinase； cell division protein kinase 8； mediator complex subunit CDK8； mediator of RNA polymerase II transcription subunit CDK8； protein kinase K35； 周期素依赖性激酶8； 周期素依赖性激酶8(CDK8)；
背景信息：
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016][provided by RefSeq, Jul 2008].
