基因名：
CDK2
产品别名：
CDKN2； p33(CDK2)； CDK2； cyclin dependent kinase 2； cyclin dependent kinase 2； cyclin-dependent kinase 2； cdc2-related protein kinase； cell division protein kinase 2； p33 protein kinase； 周期素依赖性激酶2； 周期素依赖性激酶2(CDK2)； 磷酸化周期素依赖性激酶2；
背景信息：
Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells.
