基因名:
CD70
产品别名:
CD27-L; CD27L; CD27LG; LPFS3; TNFSF7; TNLG8A; CD70; CD70 molecule; CD70 molecule; CD70 antigen; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand 8A; tumor necrosis factor ligand superfamily member 7; CD70(Trimer)蛋白; 肿瘤坏死因子配体超家族成员7(TNFSF7);
背景信息:
CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.