基因名：
CD3D
产品别名：
CD3-DELTA； CD3DELTA； IMD19； T3D； CD3D； CD3 delta subunit of T-cell receptor complex； CD3 delta subunit of T-cell receptor complex； T-cell surface glycoprotein CD3 delta chain； CD3 antigen, delta subunit； CD3 delta； CD3d antigen, delta polypeptide (TiT3 complex)； CD3d molecule, delta (CD3-TCR complex)； OKT3, delta chain； T-cell receptor T3 delta chain； CD3d分子(CD3d)； CD3D蛋白；
背景信息：
CD3D is a single-pass type I membrane protein which Contains 1 ITAM domain. T cell receptor-CD3 complex (TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID), which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
