基因名：
CAMK2D
产品别名：
CAMKD； CAMK2D； calcium/calmodulin dependent protein kinase II delta； calcium/calmodulin dependent protein kinase II delta； calcium/calmodulin-dependent protein kinase type II subunit delta； CaM kinase II delta subunit； CaM-kinase II delta chain； CaMK-II delta subunit； calcium/calmodulin-dependent protein kinase (CaM kinase) II delta； calcium/calmodulin-dependent protein kinase type II delta chain； 钙/钙调素依赖蛋白激酶2D(CaMKIIδ)；
背景信息：
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated a, ∫, (C) and ?, which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but phosphorylation by a CaMK is also required for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.
