基因名：
CACNA1E
产品别名：
BII； CACH6； CACNL1A6； Cav2.3； DEE69； EIEE69； gm139； CACNA1E； calcium voltage-gated channel subunit alpha1 E； calcium voltage-gated channel subunit alpha1 E； voltage-dependent R-type calcium channel subunit alpha-1E； brain calcium channel II； calcium channel, L type, alpha-1 polypeptide； calcium channel, R type, alpha-1 polypeptide； voltage-dependent calcium channel alpha 1E subunit； voltage-gated calcium channel alpha subunit Cav2.3； L型钙通道蛋白a1亚型6； R-型电压依赖钙离子通道α1E亚基(CACNa1E)；
背景信息：
Calcium channels mediate the influx of calcium ions into the cell following membrane polarisation. R-type calcium channels such as Cav2.3 belong to the "high voltage-activated" group and are blocked by nickel. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Each of these proteins exists as multiple isoforms, either encoded by different genes or arising from alternative splicing of transcripts. Cav2.3 is an alpha-1 subunit and has 24 transmembrane segments, which form the pore through which ions pass into the cell. Calcium channels containing the Cav2.3 subunit may be involved in the modulation of firing patterns of neurons, which is important for information processing.
