基因名：
BMI1
产品别名：
FLVI2/BMI1； PCGF4； RNF51； flvi-2/bmi-1； BMI1； BMI1 proto-oncogene, polycomb ring finger； BMI1 proto-oncogene, polycomb ring finger； polycomb complex protein BMI-1； B lymphoma Mo-MLV insertion region 1 homolog； BMI1 polycomb ring finger oncogene； BMI1 polycomb ring finger proto-oncogene； murine leukemia viral (bmi-1) oncogene homolog； polycomb group RING finger protein 4； polycomb group protein Bmi1； ring finger protein 51； 多梳家族环指蛋白4(PCGF4)； 组蛋白相关Bmi1；
背景信息：
The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.
