基因名：
BCR
产品别名：
ALL； BCR1； CML； D22S11； D22S662； PHL； BCR； BCR activator of RhoGEF and GTPase； BCR activator of RhoGEF and GTPase； breakpoint cluster region protein； BCR, RhoGEF and GTPase activating protein； BCR/FGFR1 chimera protein； FGFR1/BCR chimera protein； breakpoint cluster region； renal carcinoma antigen NY-REN-26； 断裂点簇集群区(BCR)； 磷酸化T淋巴细胞受体；
背景信息：
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
